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Phendimetrazine has been available for more than forty years. This diet pill stimulates the satiety (feeling of fullness) center in the limbic and hypothalamus regions of the brain where appetite and hunger are controlled.

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Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

Uses Phendimetrazine is a sympathomimetic appetite suppressant. Sympathomimetic appetite suppressants are used in the short-term treatment of obesity. Phendimetrazine's appetite-reducing effect tends to decrease after a few weeks. Because of this, Phendimetrazine is useful only during the first few weeks of a weight-loss program. Sympathomimetic appetite suppressants can help you to lose weight while you are learning new ways to eat and to exercise. Changes in eating habits and activity level must be developed and continued long-term in order for you to continue losing weight and to keep the lost weight from returning.

How to take this medication: In order to prevent trouble with sleeping, if you are taking:

• One dose of Phendimetrazine a day, take it about 10 to 14 hours before bedtime.
• More than one dose of Phendimetrazine a day, take the last dose of the day about 4 to 6 hours before bedtime.

For patients taking a long-acting form of this medicine: Swallow these capsules or tablets whole. Do not break, crush, or chew before swallowing. For patients taking mazindol: This medicine may be taken with food, if needed, to prevent stomach upset. Take this medicine only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much is taken, it may cause unwanted effects or become habit-forming. If you think this medicine is not working properly after you have taken it for a few weeks, do not increase the dose. Instead, check with your doctor.

Precautions Your doctor should check your progress at regular visits to make sure that this medicine does not cause unwanted side effects. If you think this medicine is not working properly after you have taken it for a few weeks, do not increase the dose. Instead, check with your doctor.

Do not take an appetite suppressant with or less than 14 days after taking a monoamine oxidase (MAO) inhibitor. If you do, you may very suddenly develop extremely high blood pressure. Taking a sympathomimetic appetite suppressant may cause a positive result in urine screening tests for amphetamines. Sympathomimetic appetite suppressants may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of developing dental disease, including tooth decay, gum disease, and fungus infections.

This medicine may cause some people to feel a false sense of well-being or to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert. Before having any kind of surgery, dental treatment, or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine. Taking appetite suppressants together with medicines that are used during surgery or dental or emergency treatments may cause serious side effects.

Check with your doctor immediately if you notice a decrease in your ability to exercise, if you faint, or if you have chest pain, swelling of your feet or lower legs, or trouble in breathing. These may be symptoms of very serious heart or lung problems.

If you have been taking this medicine for a long time or in large doses and you think you may have become mentally or physically dependent on it, check with your doctor. Some signs of dependence on appetite suppressants are:

• a strong desire or need to continue taking the medicine.
• a need to increase the dose to receive the effects of the medicine.
• withdrawal side effects (for example, mental depression, nausea or vomiting, stomach cramps or pain, trembling, unusual tiredness or weakness) when you stop taking the medicine.

For patients with diabetes this medicine may affect blood sugar levels. If you notice a change in the results of your urine or blood sugar tests or if you have any questions, check with your doctor. If you have been taking this medicine in large doses or for a long time, do not stop taking it without first checking with your doctor. Your doctor may want you to reduce gradually the amount you are taking before stopping completely. This will help prevent withdrawal side effects.

Drug interactions Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking appetite suppressants, it is especially important that your health care professional know if you are taking any of the following:

• Amantadine (e.g., Symmetrel)
• Amphetamines
• Caffeine (e.g., NoDoz)
• Chlophedianol (e.g., Ulone)
• Cocaine
• Medicine for asthma or other breathing problems
• Medicine for colds, sinus problems, or hay fever or other allergies (including nose drops or sprays)
• Methylphenidate (e.g., Ritalin)
• Nabilone (e.g., Cesamet)
• Pemoline (e.g., Cylert)—Using these medicines with sympathomimetic appetite suppressants may increase the central nervous system (CNS) stimulant effects, such as irritability, nervousness, trembling or shaking, or trouble in sleeping
• Appetite suppressants (diet pills)
• Selective serotonin reuptake inhibitors (citalopram [e.g., Celexa], fluoxetine [e.g., Prozac], fluvoxamine [e.g., Luvox], paroxetine [e.g., Paxil], sertraline [e.g., Zoloft])—It is not known whether using two different appetite suppressants together or using a sympathomimetic appetite suppressant with a selective serotonin reuptake inhibitor is safe and effective. There have been some serious unwanted effects on the hearts of people who used two different appetite suppressants together
• Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [e.g., Marplan], isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., Parnate])—Do not take an appetite suppressant while you are taking or less than 14 days after taking a monoamine oxidase (MAO) inhibitor. If you do, you may develop sudden extremely high blood pressure
• Tricyclic antidepressants (amitriptyline [e.g., Elavil], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g., Aventyl], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil])—Using these medicines with sympathomimetic appetite suppressants may cause high blood pressure or irregular heartbeat

Before using this medication, tell your healthcare provider about any other drugs you are taking.

Missed dose If you miss a dose of this medicine, skip the missed dose and continue with your regular dosing schedule. Do not double doses.

Storage Store at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture. Keep this and all medications out of the reach of children.

Disposal Check the expiration dates on your medications and remove those that are outdated. Take expired medications back to your pharmacy or to your local waste disposal depot. If you are unsure if a drug is still good, check with your pharmacist.

Phendimetrazine Side Effects Appetite suppressants may cause some serious side effects, including heart and lung problems. You and your doctor should discuss the good this medicine may do as well as the risks of taking it. Check with your doctor immediately if any of the following side effects occur:

• Rare
• Chest pain
• Decreased ability to exercise
• Fainting
• Swelling of feet or lower legs
• Trouble in breathing
Check with your doctor as soon as possible if any of the following side effects occur: More common
• Increased blood pressure Less common or rare
• Difficult or painful urination
• Fast or irregular heartbeat
• Feeling that others can hear your thoughts
• Feeling that others are watching you or controlling your behavior
• Hallucinations (feeling, seeing, or hearing things that are not there)
• Headache (severe)
• Mental depression
• Numbness, especially on one side of the face or body
• Skin rash or hives
• Sore throat and fever (with diethylpropion)
• Talking, feeling, and acting with excitement and activity you cannot control
• Unusual bleeding or bruising (with diethylpropion)

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

• More common
• Constipation
• Dizziness or lightheadedness
• Dryness of mouth
• False sense of well-being
• Headache
• Irritability
• Nausea or vomiting
• Nervousness or restlessness
• Stomach cramps or pain
• Trembling or shaking
• Trouble in sleeping

After the stimulant effects have worn off, drowsiness, unusual tiredness or weakness, or mental depression may occur.

• Blurred vision
• Changes in sexual desire or decreased sexual ability
• Diarrhea
• Drowsiness
• Frequent urge to urinate or increased urination
• Increased sweating
• Unpleasant taste

These and other side effects may occur. If the side effects persist or become worse, notify your doctor immediately.

Notes This is a prescription medication and should NOT be shared with others.

Phendimetrazine is a popular weight loss medication used to treat obesity. Phendimetrazine is a sympathomimetic appetite suppressant.

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